Many people are looking for supplements to help them rejuvenate or slow down the passing years. In recent months, Dmae has become an essential complement in many beauty routines, but also in training. Is it proven to work?
DMAE, also known as dimethylaminoethanol, dimethylethanolamine, or Deanol, is a compound that is sometimes used as an ingredient in lotions, creams, and other skin care products. It is also available in dietary supplement form, which many claim is more effective.
DMAE is a compound that many people believe can positively affect mood, improve memory, and improve brain function. It is also believed to have benefits for aging skin. Although there aren’t many studies on AMD, proponents believe it may have benefits for a number of conditions, including attention deficit hyperactivity disorder (ADHD), Alzheimer’s disease, dementia, and depression.
Dmae occurs naturally in the body, but is also found in fatty fish, such as salmon, sardines, and anchovies. It is thought to work by increasing the production of acetylcholine , a neurotransmitter that is crucial in helping nerve cells send signals. Acetylcholine helps regulate many functions controlled by the brain, including REM sleep, muscle contractions, and responses to pain.
DMAE can also help prevent the buildup of beta-amyloid in the brain. Too much beta-amyloid has been linked to age-related decline and memory loss.
DMAE’s impact on acetylcholine production and beta-amyloid buildup may make it beneficial for brain health, especially as we age.
There are not many studies on AMD, and most of them are very old. However, there are some smaller studies and anecdotal reports that suggest it may have beneficial effects.
Reduces wrinkles and firms sagging skin
A clinical study found that a facial gel containing 3% DMAE was beneficial in reducing fine lines around the eyes and on the forehead when used for 16 weeks. The study also found that it improved the shape and fullness of the lips, as well as the overall appearance of aged skin. It has been suggested that DMAE can hydrate the skin and improve the appearance of the skin.
Mesotherapy (cutaneous injections with tiny needles) with DMAE and amino acids increases collagen levels and has remarkable anti-aging effects in rodents.
A small amount of scientific evidence indicates that DMAE may reduce memory loss associated with Alzheimer’s disease and dementia, but there are no studies to support this claim.
A special formulation, DMAE pyroglutamate (1,500 mg/day for 6 days), reversed short-term cognitive decline in healthy men. Pyroglutamate itself can increase acetylcholine levels and cognition, and probably contributes to the results. Also, the study on human subjects lacks a control group.
Centrophenoxine, with DMAE as the active component, improves long-term memory and increases alertness in healthy older adults. The same drug improved memory in 50 elderly patients with dementia. However, DMAE failed to improve cognition in studies of older people with mild memory loss and Alzheimer’s disease.
Improve sports performance
Anecdotal evidence claims that DMAE may help improve athletic ability when combined with other vitamins and supplements. However, more research is needed to support this.
Studies of children during the 1950s, 1960s, and 1970s found evidence that this supplement helped reduce hyperactivity, calm children, and help them focus in school. However, no recent studies have been done to support or deny these findings.
Some people believe that DMAE can help improve mood and improve depression. A small study in people who had age-related cognitive decline found that DMAE reduced depression, anxiety, and irritability. He also found that it was helpful in increasing motivation and initiative.
In addition, Centrophenoxine, which contains DMAE, reduces anxiety in people exposed to stress. In another rodent study, researchers looked at its ability to increase brain levels of dopamine and serotonin, which are essential for good mental health.
Possible Side Effects
Very little is known about the safety of DMAE supplements. However, there is some concern that it may trigger certain side effects, including increased blood pressure, upset stomach, headaches, muscle tension, drowsiness, confusion, and irritability.
Pregnant and lactating women and women who are trying to conceive should not take DMAE, as it can cause neural tube defects. This supplement impairs choline metabolism in embryos, leading to birth defects and growth retardation.
Also, people with bipolar disorder or epilepsy should not use it either. When used topically, DMAE can cause skin irritation.
Dosage and preparation
There is not enough scientific evidence to establish a safe or effective dose of DMAE. Doses have been used in scientific studies. For example, in a study that examined the athletic performance benefits of DMAE, study participants took 300 to 2,000 mg per day . The safe and effective dose for each person may depend on variables including age, gender, and medical history. It is recommended to speak with a healthcare provider for personalized advice.
DMAE was once sold as a prescription drug for children with learning and behavior problems under the name Deanol. It was withdrawn from the market in 1983 and is no longer available as a prescription drug. Today, DMAE is sold as a dietary supplement in capsule and powder form. Dosing instructions vary by brand, so it’s important to follow package directions and buy DMAE only from reputable sources.
However, this supplement is available as a serum for use on the skin. It is also an ingredient in some cosmetics and skin care products.